Entrepreneurship is as an essential element for stimulating nation's growth and development. Women entrepreneurship is acquiring attention from the public in the light of evidence of the potential for economic growth and development of new business creation, particularly in e-commerce. Through economic reforms, women are rising their numbers to own and run businesses, particularly in online businesses where information technology has the power to grow the industry and change the way business is run. Considering acknowledgement of women entrepreneurs playing a key role in economic development, their growth has remained substantially undermined. Women entrepreneurs, however, face a wide range of challenges, both in developing and growing their business activities. The forthcoming research paper was aimed at investigating the challenges of e-commerce entrepreneurship that the Klang Valley woman faces in the present times. For this exploratory analysis the survey questionnaire was implemented using convenience sampling process. The data was analysed using descriptive analyses as well as normality and comparison evaluates. The data used in this study were collected from a sample of 200 respondents. The empirical survey data analysis on distinguish five key important factors that hamper the growth of female entrepreneurship in Klang Valley, namely personal, social, financial, marketing and technological. The study concluded that women entrepreneurs face constraints attributable to access to capital, lack of expertise and entrepreneurial education accompanied by difficulties in selling their products online, such as challenges of networking. Recommendations for future researchers have been put forward at the end of this paper.