Effects of Flouride on Ca3 Region of Hippocampus in Adult Albino Rats
Vol. 3 No. 7 (2013), Articles
Vol. 3 No. 7 (2013)

Effects of Flouride on Ca3 Region of Hippocampus in Adult Albino Rats

Nazim Nasir
Department of Applied Medical Sciences, College of Applied Medical Science, KKU, Abha, KSA
Mohammad Rehan Asad
Department of Basic Sciences, College of Medicine, Majmaah University, Majmaah, KSA
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Keywords

Dentate gyrus, Hippocampus, Fluorine, Neuronal density, Neuro-degeneration, CA3 region.

How to Cite

Nasir, N. ., & Asad, M. R. . (2013). Effects of Flouride on Ca3 Region of Hippocampus in Adult Albino Rats. Journal of Asian Scientific Research, 3(7), 729–733. Retrieved from https://archive.aessweb.com/index.php/5003/article/view/3526
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Abstract

The pilot study is conducted using 30 adult albino rats (200-250gm). They were divided into one control and one experimental group. Group 1 is Control (Ctrl), which received food and water ad-libitum, experimental group received, 20 ppm of sodium fluoride (NaF) for 7 weeks. The body weights and physical activity was significantly reduced in experimental group, whereas fluoride levels of hippocampus, was greatly increased. Light microscopy of the hippocampus, showed reduced neuronal density more pronounced in the CA3 region of hippocampus. Neuronal density was reduced to 84.2 cells/ cu mm in experimental group as compared to 132.2 cells/ cu mm in control.

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