Abstract
The study examined the knowledge attitude and opinion of the university undergraduates to HIV/AIDS and its screening in Edo State Nigeria. The sample comprised 600 undergraduates randomly selected from three universities in Edo State. A researcher constructed questionnaire was used to test the five hypotheses formulated for the study. One-way Analysis of Variance (ANOVA) and independent t-test statistical techniques were used for data analysis. The findings showed that the students had very good level of knowledge regarding the mode of transmission of the disease and HIV screening centres. However, the good knowledge did not translate itself into positive attitude towards those living with HIV/AIDS in the hostel. There was also a significant difference in their opinion of how one gets infected with the virus. The study therefore recommended that counselling and public enlightenment should be intensified.