Pharmacy has been regarded as one of the most stressful professions and workplace depression within this professional category has been rarely investigated. Given these conditions, it seems earnest to give consideration to the workplace factors affecting pharmacists’ performance and causing workplace depression among them. Thus, the purpose of this study is to examine antecedents and outcomes of workplace depression. Moreover, we have also investigated the moderating effect of managerial support and pay benefits. Data was collected from 235 pharmacists working in private hospitals. Smart PLS was used to examine the statistical outcomes of the study. The result of the study revealed that distributive justice and workload are significantly related to the job depression. Job depression is the predictor of job Performance and moderating effect of managerial support is also significant between the relationship of work overload and job depression. To the best of authors' knowledge, this study is the first to examine antecedents of job depression among pharmacy residents in Pakistan. Moreover, our study will encourage scholars and practitioners to work in this particular area.