This study investigated differences related to fear of COVID-19, fear to leave home and ten aspects of working adults’ life between genders and working places. 455 working adults in Malaysia participated in the online survey through convenience sampling technique. The results showed that the main effect for gender was significant (Wilks’ Λ = 0.88, F(2, 375) = 4.10, p = 0.001, multivariate η2 = 0.12.), indicating that fear of COVID-19, fear of leaving home, and aspects of working adults’ life tests differ for males and females. Moreover, the results showed that the main effect for working place was significant (Wilks’ Λ = 0.94, F(2, 375) = 1.81, p = 0.045, multivariate η2 = 0.06) but the interaction of gender and working place was not significant. Furthermore, individuals working from home reported higher fear to leave home and more severe effect on occupational aspect than those who worked at the workplace.