Abstract
The majority of de novo structural chromosome aberrations in fetuses and newborns are considered being of cells of mammals for DNA damage during gametogenesis. 4617 chromosomal studies performed during 19 years (from 1992 to 2011), at Hospital Para El Niño Poblano in México, a total of 1596 patients showe positive for DNA aberrations. Among these studies population, 0.23% (11) chromosome translocations were observed. From this data, two male pediatric patients are described, with 1;4 and 6;9 chromosome translocations. Chromosome changes are classified as structural or numeric alterations respectively, and abnormal cell development has been associated with these two specific chromosomal translocations. The patients in this study were then analyzed and compared both hematological and compared to their clinical features.