Seventeen oxyimino-cephalosporins-resistant Klebsiella strains were isoleted from urines clinical samples from patients from various service units of University Hospital complex Paediatric Charles De Gaulle (CHUP-CDG) in Burkina Faso. These strains were resistant to at least one oxyimino-cephalosporin. They were identified as producer of extended spectrum β-lactamases (ESBL) by double-disk synergy test between amoxicillin–clavulanate and cefotaxime, ceftriaxone or ceftazidime. The ESBL was identified as CTX-M-15 for the 17 strains by sequencing of PCR products amplified with primers designed for blaCTX-M genes. This is the first description of this enzyme in Burkina Faso.